Abstract: This paper takes a landslide in south Qinghai Province as an example, on the basis of the analysis of regional geology and landslide characteristics, analyzed the mechanism of landslide and factors influencing landslide, determined the sliding mode, selected rational parameters for landslide stability calculation, carried out analysis of landslide stability according to the calculation result, summarized the mechanism and reasons of landslide in the area, providing reference experiences for similar geological disaster management. Through the analysis and calculation it concludes:the cause for occurrence of landslide hazards is poor lithology, frozen soil depth in the area where landslide is located is larger, regional temperature difference between summer and winter is large, surface water is frozen in winter and melt in next summer, inducing muddy clay and shale as well as lower cohesion, sliding body creeps continuously and slides down. By using transfer coefficient method, the stability of landslide in different conditions is calculated. The results show that under the natural conditions, shallow sliding surface of landslide is in creep deformation condition, deep sliding surface is basically stable, in consideration of rainstorm and seismic conditions, the landslide is in unstable state.