Abstract: The drainage and production control method has significant impact on the permeability of coalbed methane reservoir. Based on the main control factors of the permeability at different stages of drainage and production of coalbed methane wells, this paper puts forward targeted drainage and production countermeasures with the goal of improving the permeability. When the bottom-hole flow pressure was greater than the original reservoir pressure, the step-down velocity was between 0.08 and 0.1 MPa/d to reduce fracturing fluid and velocity-sensitive damage. When the bottom hole flow pressure was between reservoir pressure and desorption pressure, the pressure could be reduced at a rate less than 0.03 MPa/d to avoid aggravating the "permeability funnel" of the reservoir. When the desorption pressure was 0.2-0.3 MPa, the pressure decreased at the rate of 0.01 MPa/d. When the pressure was stabilized for 30 days near the desorption pressure, the casing pressure was controlled at about 0.2-0.3 MPa after desorption, so as to avoid the decrease of water-phase permeability caused by two-phase flow. The permeability of reservoir was improved by increasing matrix shrinkage with variable speed. In the stable production period, the reasonable stable production could be determined by increasing production per unit pressure drop to achieve long-term high and stable production of CBM wells. The field test shows that the method is effective.