Abstract: According to the prediction of water inrush from coal seam floor, based on the summarization of existing water inrush prediction methods and theories, the feature selection experiment shows that water pressure, distance from the working surface, sandstone section thickness, coal thickness, coal seam inclination, fault throw, fissure zone, mining area, mining height and strike length are the main factors affecting the occurrence of water inrush. These factors are complex and non-linear. A water inrush prediction model based on long short-term memory(LSTM) neural network was proposed. The data of the coal mine water inrush case was used as sample data to train the model. Finally, the LSTM neural network model is compared with the genetic algorithm-back propagation(GA-BP) neural network model and back propagation(BP) neural network model. The experimental results show that the LSTM neural network model has higher prediction accuracy, better stability, and is more suitable for coal seam floor water inrush prediction.