Abstract: Junggar basin is an important energy exploration base in China. The exploration of its uranium resources has been difficult to break through. By secondary development of the coal exploration results of Kamusite area in eastern Junggar basin, further drilling verification, industrial uranium orebodies have been found. The Middle Jurassic Toutunhe Formation is the ore-bearing target in this area, has very good prospecting prospect and research significance. In order to understand the petrological characteristics and uranium mineralization of the target-layer sand body in this area, through the detailed field geological survey, borehole observation and other methods, with the advanced analysis and testing technology, combined with the interior geology work and previous achievements, the characteristics of clastic compositions, alteration and diagenesis of sandstone in this area were studied. And the composition of uranium ore and the mineralization of epigenetic uranium were studied. The results show that sandstone diagenesis is strong in this area, has good conditions for developing uranium reservoirs, and the uranium mineralization is better, the main uranium ore types are coffinite and brannerite.