Abstract: Waterlogged area in coal field is of great importance for the health of local residents. In this paper, heavy metals (Cr,Cd,Zn,Cu,Pb,Ni and Fe)from 12 water samples in mine subsidence area were monitored in Panyi coal mine of Huainan. The human health risk caused by heavy metals through the ingestion ways were evaluated and analyzed using the water environmental health risk assessment model recommended by USEPA. It has been found that the carcinogenic risk values in the water body of the study area were between(5.06~8.06)×10^-6/a, according to the health risk standards recommended by the Ministry of Environmental Protection of China, there is a health risk in the water body of the study area. Among them, the carcinogenic risk of Cr accounted for 98.52% of the total carcinogenic risk. Non-carcinogenic health risk values were around 10^-10/a, the health risk is not obvious, and the contribution of non-carcinogenic health risk was the order of Cu > Pb > Fe > Cr > Cd > Ni > Zn. Among them, Cu had the largest contribution, accounting for 48.62% of the total non-carcinogenic risk value. At the same time, research results also indicated that the carcinogenic risk in the study area constituted 99.99% of the total health risk, indicating that the total health risk essentially consisted of carcinogenic risk, and carcinogenic risk was almost consisted of Cr.