Abstract: The paper, taking an engineering project of a pipeline crossing a landslide as background, used the software of finite element analysis ANSYS to set up the mechanical numerical simulation model of a pipeline crossing a landslide, and software FLAC3D to conduct simulation study of load and deformation of the pipeline, adopted analytical calculation method of statics to analyze and study the deformation and stress status of the pipeline, obtained the characteristcs such as strain and stress of the pipeline, as well as landslide displacement during the critical failure of the pipeline. The results of the two methods were identical, and showed that when the pipeline passed cross the landslide, the two ends of the pipeline were the most easy to failure. The deformation of the middle of the pipeline in the landslide was the biggest, and the deformation at two sides became smaller, the deflection deformation curve exhibited normal distribution. The stress at the two sides of the pipeline was the biggest,the middle of the pipeline was positively curved, the two sides of the pipeline were negatively curved, which was in accordance with the bending moment pattern of the uniform load beared on the fixed simple support beam at the two ends. To conduct the numerical simulation analysis on the basis of analysis of statistics has thereoretically guiding signficance for the research on the geological hazard of pipeline.