Abstract: Ion ratio method was employed to analyze the hydrochemical characteristics of groundwater in the east of Fengfeng mining area to provide the basis for determining the plausible phase in hydrogeochemical simulation. The simulation of groundwater-rock interaction was conducted by using computer code PHREEQC. Mineral saturation indexes were calculated to assess the equilibrium status of groundwater-minerals reactions. Phase mole transfers in water-minerals interaction were calculated through the mass balance simulation. The results show that calcite and dolomite were supersaturated, would precipitate under appropriate conditions. Halite and gypsum were undersaturated, they would continue to dissolve under appropriate conditions. Along Ordovician limestone groundwater flow paths, dolomite, halite and gypsum dissolved, calcite precipitated, and cation exchanges took place from Fifth coal mine to First coal mine. The simulation of the mine groundwater-rock interaction could play an important role in the study of influencing factors of mine hydrogeochemical evolution.