Abstract: Taking well GZ-01 in Guanzai mine of Guizhou Province as an example, aiming at the characteristics such as broken soft seams, poor permeability, thin and multiple seams, the fracturing technology suitable to the geological and reservoir conditions in the mine was discussed from the view of the target layers(intervals), perforation, formula of the fracturing fluid, proppant agent, fracturing mode and scale. The results showed that the dilatability of coal seams in the mine is low, add expansion can be restrained by adding 1.0% KCl; High sand ratio, large amount of fluid, middle displacement were used to conduct segmental fracturing of multilayers.