Abstract: The safe mining of coal resources in China has been seriously affected by water inrush from seam floor. In order to solve the problem in forecasting water inrush from coal seam floor, in the paper a new software system forecasting of water inrush from seam floor is developed in MATLAB on the basis of the forecast system of water inrush probability indexes. By means of analyzing and processing lots of data such as geology, hydrogeology and so on, major controlling factors and secondary factors leading to water inrush from coal seam floor are determined and then the corresponding weights are given to make the factors of water inrush quantified, and every weight can change flexibly in different mine areas and different controlling factors. Thematic map of each major factor is drawn and empowerment summation mathematical model is established. According to the different weights of the major factors, the water inrush subarea chart of probability index is drawn and the probability indexes of water inrush are calculated. After the system being applied in engineering practice, it proves that the predicted result is consistent with the actual situation.