Abstract: Differential evolution (DE) is firstly introduced into estimating hydrogeology parameters in this paper.The DE is one of the intelligent optimization methods, it extracts the differential information from the current population of solutions to guide further search.DE makes good balance between global optimization and local searching ability by introducing a method like Singleton method.The general principle of the DE is introduced, so as the main computing procedures.Some hydrogeology parameters in Theis formula are estimated with DE while the data is calculated according to analytical solutions with supposing parameters.The result shows that DE per-forms well and is worth to applying in estimating hydrogeology parameters and without artificial influence.