Abstract: During drilling, resonance is generated when the natural frequency of the drilling rod is consistent with the external excitation frequency. This will cause fatigue-failure of the drilling rod and serious consequences. To avoid this, a drilling rod vibration measurement system based on Micro-Electro-Mechanical System was designed. This system uses the three-axis acceleration sensor to measure the acceleration of the drilling rod in three directions. The upper computer software written in LabVIEW can storage, upload, display and process data. Then the fast Fourier Transform was taken to analyze the vibration frequency of the drilling rod. Finally the system is installed on the drilling rod for testing and analyzing the longitudinal, transverse, torsional vibration frequency and rotational speed of the drilling rod. It provides accurate information for adjusting the drilling parameters and avoiding resonance damage of the drilling rod.