Abstract: In order to clarify the coupling relationship between oil and gas of Mesozoic coal-bearing measures(reservoir) and uranium deposits(points) in Huangling area, field geology investigations of boreholes and sections, analysis and processing of borehole data and experimental data, and integration of reservoir and uranium(point) information were carried out. Collation and systematic study of tectonic-sedimentary systems of Mesozoic coal-bearing mesure, uranium geological characteristics, oil and gas geology characteristics, spatial distribution relationship between hydrocarbon reservoirs and uranium deposits, genetic relationship between hydrocarbon-bearing fluids and uranium-associated altered minerals, and the time relationship between hydrocarbons and uranium mineralization were discussed. The study shows that the uranium deposits of Mesozoic coal-bearing(spots) measures were mostly distributed near the boundary of the bedrock erosion or small faults, and the horizontal projection is located at the periphery of the favorable oil and gas facies belt. The hydrocarbon fluid components and the intermediate products of the coalbed gas may have participated in the re-dox reactions, then the uranium associated altered minerals such as pyrite, clay minerals, and calcite have been produced. The main hydrocarbon generation period of Mesozoic coal-bearing source rocks was overall earlier than the main miner-alization period of uranium deposits, and hydrocarbon fluids may have migration time conditions that affected uranium mineralization.