Abstract: The exploitation of CBM is different from conventional gas.The water in coal needs to be drained in CBM wells before the gas come out, so well grid pattern is usually used in CBM exploitation in order to get better effect of water drainage and depressurization, the arrangement of well pattern directly affects the success of CBM development and the level of ultimate recovery.This paper presents the optimization design principle of CBM well pattern and factors such as well interference, anisotropy, well spacing, well density and direction, then conducts optimization design of CBM well pattern aiming at an area in Ordos basin by numerical simulation software, thus providing reasonable basis for development program design of the area.