Abstract: The application of the conventional seismic inversion in reservoir prediction is constrained by many factors, while the technology of random inversion combines effectively the random simulation technology and conventional seismic inversion, and integrates geology、logging and 3-D seismic data, which can make up for the lack of enough information about logging and improve prediction accuracy, what is more, this technology can play a positive role in the rolling stage of exploitation. The technology was applied in a three-dimensional work area to predict permeable sandstone in layers Eq41, Eq42and Eq43, which achieves good results and plays a positive role in the rolling stage of exploitation.