Abstract: On the basis of geology, data of groundwater long-terme observation and different geotechnic engineering investigation, the genesis and types of karst collapse in Meitanba mining area were studied, and the succeptibity of karst collapse was predicted by zonation. The results indicated that the internal factor for formation of karst collapse in the area was karst development of Maokou Limestone, the external factors was karst water drainage at great amount. Factors influencing karst collapse are mainly related to conditions of Karst development, groundwater, overlying strata, topography and morphology as well as human activities. From prediction, groundwater run-off zones in Xiaohe, Heshiqiao, Dachengqiao,Yangquanhu are areas very prone to collapse, Oujiadachong, Weishui, Washicong,Baishuitang, Xeijiacitang where several surface water bodies are areas prone to collapse, several coal mining areas are hard to collapse, Fuquanshan and Gutantgpo are areas basically stable and stable. Investigation verified that the prediction was in accordance with the reality.