Abstract: For the purpose of studying the influence of pipeline crossing on the riverbed scouring depth of the coal measure soil, different pipeline depths, pipe diameters and scouring velocity were set up to carry out scour simulation tests based on the clay and sandy riverbed model test equipment. The SPSS software was used to perform multiple linear regression analysis on the riverbed scouring depth and the above factors. The results show that the pipeline depth, pipe diameter and scouring velocity are responsible for 71.4% to 80.6% of the change of scour depth. The burial depth significantly and negatively affects the scouring depth; the pipe diameter and scouring velocity significantly and positively affect the scouring depth. Pipeline crossing will destroy the original cement state between the particles of the riverbed and strengthen the scouring effect of the water flow. With the influence of buried depth and pipe diameter on the scour depth being considered, the obtained linear regression equation was used to verify the safety of a pipeline crossing project in Zhuhai City, where the verification results have shown the feasibility of the regression equation. The research results can provide a certain reference for pipeline crossing engineering design.